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Arrayed siRNA screens are a powerful tool to look at very precise perturbations in cellular pathways.
Revvity’s Dharmacon™ CRISPR portfolio expands with validated CRISPR guide RNAs for complex but critical gene targets, as well as DNA cutting controls for screen normalization in sensitive assays.
Functional genomic screening allows for the elucidation of the mechanism of action of exogenous agents which modulate intracellular gene function such as pharmaceutical agents and other compounds. Read about the various considerations, approaches and interpretations when conducting a screen to investigate novel compounds and analyzing the screening data.
プール化CRISPR薬剤遺伝子スクリーニングでは、ポジティブまたは耐性スクリーニングとネガティブまたは感受性スクリーニングという2つの選択メカニズムを適用することができ、それぞれに様々な考慮事項や使用法があります。
Functional Genomic and Cell Panel Screening can individually provide comprehensive data sets to support therapeutic development, but when utilized in combination they identify novel targets which are cross-validated by independent approaches.
当社のCRISPRiプラットフォームが新しいdCas9融合タンパク質と化学合成sgRNAを使用して、遺伝子の特徴付けとアレイ化されたスクリーニングのワークフローを改善します。
Learn about Horizon's CRISPRsc (CRISPR single cell) platform that combines the flexibility of pooled screening with the power of transcriptomics at single cell resolution.
Gisela Jimenez-Duranらによる最近の論文は、Horizon Discoveryによって実施された全ゲノムCRISPRノックアウトスクリーニングが、炎症誘発性マクロファージを調節できる既存の阻害剤をどのように同定したかをわかりやすく示しています。
A summary of a recent publication in The CRISPR Journal showing that Horizon's integrated pooled CRISPRko and high throughput cell panel screening platform together offer clinically relevant information for therapeutic targets.